Symbol
Name
ID

Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
MGI:88582

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes

Increased circulating androstenedione concentration

Increased circulating dehydroepiandrosterone-sulfate concentration

Increased serum testosterone level

Increased circulating 17 hydroxypregnenolone concentration

Elevated circulating 17-hydroxyprogesterone concentration

Elevated circulating 21-deoxycortisol concentration

Elevated serum 11-deoxycortisol

Adrenal hyperplasia

Congenital adrenal hyperplasia

Impaired cortisol response to corticotropin releasing hormone stimulation test

Decreased circulating renin level

Adrenal insufficiency

Decreased circulating aldosterone level

Hyperaldosteronism

Adrenocorticotropic hormone excess

Adrenogenital syndrome

Precocious puberty in males

Premature pubarche

Disease(s) Associated with CYP11A1

congenital adrenal hyperplasia

congenital adrenal insufficiency

Mouse Phenotypes

dilated bile duct

abnormal adrenal gland morphology

abnormal adrenal cortex morphology

abnormal adrenal gland zona fasciculata morphology

abnormal adrenal gland zona glomerulosa morphology

abnormal adrenocortical cell morphology

enlarged adrenocortical cells

absent adrenal chromaffin cells

enlarged adrenal glands

small adrenal glands

absent bulbourethral gland

absent prostate gland anterior lobe

absent prostate gland

abnormal testis morphology

abnormal seminiferous tubule morphology

small testis

abnormal adrenal gland physiology

Availability

Mouse Genotype

Cyp11a1^tm1.1Bcc/Cyp11a1^tm1.1Bcc

Cyp11a1^{tm1b(EUCOMM)Hmgu}/Cyp11a1^{tm1b(EUCOMM)Hmgu}

Cyp11a1^tm1Bcc/Cyp11a1^tm1Bcc

Cyp11a1^tm2Bcc/Cyp11a1^tm2Bcc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23